A Novel Radial Basis Function Networks Locally Tuned with Differential Evolution for Classification: An Application in Medical Science

The classification of diseases appears as one of the fundamental problems for a medical practitioner, which might be substantially improved by intelligent systems. The present work is aimed at designing in what way an intelligent system supporting medical decision can be developed by hybridizing radial basis function neural networks (RBFNs) and differential evolution (DE). To this extent, a two phases learning algorithm with a modified kernel for radial basis function neural networks is proposed for classification. In phase one, differential evolution is used to reveal the parameters of the modified kernel. The second phase focus on optimization of weights for learning the networks. The proposed method is validated using five medical datasets such as bupa liver disorders, pima Indians diabetes, new thyroid, stalog (heart), and hepatitis. In addition, a predefined set of basis functions are considered to gain insight into, which basis function is better for what kind of domain through an empirical analysis. The experiment results indicate that the proposed method classification accuracy with 95% and 98% confidence interval is better than the base line classifier (i.e., simple RBFNs) in all aforementioned datasets. In the case of imbalanced dataset like new thyroid, the authors have noted that with 98% confidence level the classification accuracy of the proposed method based on the multi-quadratic kernel is better than other kernels; however, in the case of hepatitis, the proposed method based on cubic kernel is promising. A Novel Radial Basis Function Networks Locally Tuned with Differential Evolution for Classification: An Application in Medical Science